Wednesday, September 25, 2013

Traumatic Brain Injury - Dr. Dipnarine Maharaj MD - Palm Beach County Florida

Traumatic Brain Injury - Dr. Dipnarine Maharaj MD - Palm Beach County Florida
Before undergoing any type of medical treatment,  following any of the suggestions or making any conclusions from the this web site, please consult with your doctor to make sure what is medically appropriate for your specific health needs.  The web site contains the opinions of multiple authors intended for educational purposes with the understanding that the publications or editorials are not providing any professional services.  Nothing contained in this website should be construed as medical advice.  Readers should note that almost all uses for stem cells are considered experimental.  Dr. Dipnarine Maharaj MD, South Florida Bone Marrow/Stem Cell Transplant Institute, Stem Cell Cryobank, or any of its agents, associates, and affiliates, disclaim any liability, loss or risk, directly or indirectly of the application of any of the contents of the website

Thursday, September 5, 2013

NFL, Under Armour, GE launch Head Health Challenge II

NFL, Under Armour, GE launch Head Health Challenge II



Representatives from the NFL, Under Armour and General Electric announce the Head Health Challenge II at an event in Baltimore on Wednesday.
Second Challenge in Head Health Initiative is collaboration to help speed diagnosis and improve treatment for mild traumatic brain injury
BALTIMORE -- The NFL, Under Armour and GE on Wednesday launched Head Health Challenge II, an open innovation challenge to award up to $10 million for new innovations and materials that can protect the brain from traumatic injury and for new tools for tracking head impacts in real time. The challenge is part of the Head Health Initiative, a collaboration to help speed diagnosis and improve treatment for mild traumatic brain injury.
Kevin Plank, Founder and CEO of Under Armour said: "As longstanding partners of the NFL and in collaboration with GE, we take great pride in our participation in the Head Health Challenge II. We are excited to harness the power of innovation and assemble the best minds in the world towards an effort to make the field of play safer across all sports and for all athletes."
NFL Commissioner Roger Goodell said: "We are very pleased to have Under Armour join our work with GE to help accelerate progress and find better ways to protect the brain from injury. This is a perfect example of our shared commitment to making the culture of sports better and safer -- especially for young athletes."
Entries are being immediately accepted at www.headhealthchallenge.com. The deadline to submit entries is January 30, 2014. In September 2014 up to 10 winners will be selected for the chance to receive as much as $500,000 each. Up to five of the potential 10 finalists will be eligible to receive as much as $1,000,000 after the second phase of judging concludes. Please visit www.ninesights.com/community/nfl-ge-grand-challenge/process#/terms-conditions for Terms and Conditions.
Specific focus areas for Head Health Challenge II include:
I. Potential to Improve the Prevention and Identification of Brain Injuries
* Technology that demonstrates clear potential to quantify head impact in real time; detect, track or monitor biologic or physiological indicators of traumatic brain injury; protect the brain from traumatic injury; mitigate or prevent short or long-term consequences of brain trauma; assist in training to prevent traumatic brain injury.
II. Monitoring and Identifying Injury
* Technology that include, but are not limited to the following:
* Monitoring and integration of directional and rotational impact force into data.
* Systems that monitor biomechanical and physiological responses to detect injury and quantify head impact exposures.
* Systems to efficiently collect, interpret and organize large quantities of real-time data.
III. Protection against Injury or its Consequences
* Materials or devices that can absorb, distribute and/or dissipate the force of impact. These include smart or active materials.
* Polymers that are comfortable, but can adapt to sudden impacts.
* Equipment that reduces the force of direct impact transmitted to the brain.
* Equipment to control axial rotation of the head.
* Novel uniforms and protective padding equipment to dissipate excessive force.
* Improve effective mass by linking the head and neck as a total system to reduce head acceleration and minimize the mechanical effect on the brain.
IV. Training
* Sensors that provide biofeedback to modify behaviors that predispose athletes to injury or its consequences.
* Improved training methods that reduce tissue and brain damage such as:
* Novel conditioning regimes.
* Neck isolation and strengthening protocols.
Sue Siegel, CEO of GE Business Innovations, said, "GE is investing to speed up the study of head health. Through this challenge, we hope to stimulate the broader ecosystem of scientists, engineers, entrepreneurs and innovators worldwide to bring their talents to this effort and accelerate the current understanding of brain trauma."
The winners of the challenges will be selected by a panel of external judges that include leading experts in brain research and engineering solutions for training and protocols. For Head Health Challenge II, these individuals are:
Kenneth M. Ford, PhD: Founder and CEO, Institute for Human and Machine Cognition (IHMC)
Gerard Gioia, PhD: Division Chief of Neuropsychology at Children's National Medical Center
Kevin M. Guskiewicz, PhD, ATC: Kenan Distinguished Professor, Co-Director of the Matthew Gfeller Sport-Related Traumatic Brain Injury Research and Director of the Center for the Study of Retired Athletes in the Department of Exercise and Sport Science at The University of North Carolina Chapel Hill
Colonel Dallas Hack, MD: Director of the Combat Casualty Research Program and the Chair, Joint Program Committee 6 (Combat Casualty Care), U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD
Stuart Hoffman, PhD: Scientific Program Manager for the Brain Injury Portfolio, U.S. Department of Veteran Affairs
David Hovda, PhD: Professor and Vice Chairman of Research Affairs for the Department of Neurosurgery and Director of the Brain Injury Research Center, University of California, Los Angeles
David Meaney, PhD: Associate Director at Penn Center for Brain Injury and Repair and Solomon R. Pollack Professor and Chair, Department of Bioengineering
Joseph F. Waeckerle, MD FACEP: Clinical Professor of Emergency Medicine, University of Missouri-Kansas City School of Medicine
The Head Health Initiative is a four-year, $60 million collaboration to speed diagnosis and improve treatment for mild traumatic brain injury. The goal of the program, guided by healthcare experts, is to improve the safety of athletes, members of the military and society overall. The initiative includes a four-year, $40 million research and development program from the NFL and GE to evaluate and develop next generation imaging technologies to improve diagnosis that would allow for targeting treatment therapy for patients with mild traumatic brain injury. In addition the NFL, Under Armour and GE launched two open innovation challenges to invest up to $20 million in research and technology development to better understand, diagnose and protect against brain injury. The first challenge launched in March and closed in July with more than 400 submissions from more than 25 countries and will invest up to $10 million in technologies and imaging biomarkers that address identification and management of subclinical and mild traumatic brain injury. Winners of the first challenge will be announced later this year.
-- NFL Communications

Monday, August 19, 2013

DOD partners to combat brain injury - Suggested By Dr. Dipnarine Maharaj MD

DOD partners to combat brain injury - Suggested By Dr. Dipnarine Maharaj MD

August 16, 2013
By Ellen Crown, U.S. Army Medical Research and Materiel Command
Military Health System Research Symposium
Col. Dallas Hack (right), director of the U.S. Army's Combat Casualty Care Research Program, Dr. Terry Rauch, Health Affairs director of medical research, discuss veterans' mental health and traumatic brain injury research and care issues during the Military Health System Research Symposium in Fort Lauderdale, Fla., Aug. 14, 2013.
FORT LAUDERDALE, Fla. (Army News Service, Aug. 16, 2013 -- Experts from the Department of Defense and the Department of Veterans Affairs gathered Aug. 14 at the Military Health System Research Symposium to discuss the future of research on mental health and traumatic brain injury.

Discussions turned toward the National Research Action Plan, or NRAP, which is the result of an executive order signed a year ago by President Barack Obama, to improve access to mental health services for veterans, service members, and military families.

The plan directs DOD and the VA to work with the U.S. Department of Health and Human Services and the U.S. Department of Education to share resources and complete certain goals. One such goal to complete within the next year is the DOD, Center for Disease Control - Brain Trauma Foundation mild traumatic brain injury, or TBI/concussion classification project to clarify what is known and unknown about mild TBI and the critical gaps that need to be addressed.

"The National Research Action Plan creates a common roadmap for medical leadership to follow as we move forward to work on incredibly complex issues," said Col. Douglas Hack, Combat Casualty Care Research program director at the U.S. Army Medical Research and Materiel Command, headquartered at Fort Detrick, Md.

"The National Research Action Plan demonstrates a dedication across multiple agencies to close critical research and care gaps, both in the military and civilian sector," said Health Affairs Director of Medical Research Dr. Terry Rauch.

Since Sept. 11, 2001, more than 2.5 million service members have deployed to Iraq and Afghanistan in Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn. The Armed Forces Health Surveillance Center data indicates there have been more than 250,000 cases of TBI in the military, between 2000 and 2012. However, more than 80 percent of these cases were the result of non-combat injuries.

"Clearly, we are not going to stop seeing traumatic brain injuries, even in times of no war," Hack said.

The NRAP also addresses frequently co-occurring conditions, such as depression, substance abuse related to alcohol, tobacco, and other drugs, including the misuse and abuse of prescription drugs, and chronic pain, each of which can complicate the prevention and treatment of post-traumatic stress disorder, know as PTSD, TBI, and suicidal behaviors.

"The interrelationships between TBI, PTSD, and suicidality are complex, to say the least," said Dr. Robert Ursano, director of the Uniformed Services University School of Medicine's Center for the Study of Traumatic Stress.

"In fact, I think it was this war that highlighted these areas in relation to each other, as an opportunity for further investigation for research and treatment," Ursano added.

Announced within the NRAP is also the creation of two joint research consortia, including the Consortium to Alleviate PTSD and the Chronic Effects of Neurotrauma Consortium. The two consortia will be established within the next six months and are within the first phase of the NRAP.

The Consortium to Alleviate PTSD is a collaborative effort between the University of Texas Health Science Center-San Antonio, San Antonio Military Medical Center and the Boston VA Medical Center, with the goal of developing the most effective diagnostic, prognostic, novel treatment, and rehabilitative strategies to treat acute PTSD and prevent chronic PTSD.

The Chronic Effects of Neurotrauma Consortium is a collaborative effort between Virginia Commonwealth University, the Uniformed Services University of the Health Sciences, and the Richmond VA Medical Center with the goal of examining the factors which influence the chronic effects of mild TBI and common comorbidities in order to improve diagnostic and treatment options.

A key point will be to further the understanding of the relationship between mild TBI and neurodegenerative disease.

"Mild traumatic brain injury is an area we need to continue to focus on, in terms of rapid evaluation, treatment and patient management," said Katherine Helmick, deputy director of the Defense and Veterans Brain Injury Center. Most service members with TBI, she said, have a mild injury or concussion.

"With a mild TBI, most service members can have a full recovery," she said.

In its first 12 months, the NRAP will focus on developing a more precise system to diagnose TBI and standardizing data on TBI and PTSD. Longer-term goals include confirming biomarkers for PTSD and TBI, identifying changes in brain circuitry after successful treatment, and exploring genetic risk factors.

"The plan lays out the next five years, but this is really a lifelong commitment," said Dr. Timothy O'Leary, acting chief officer of the Veterans Affairs Office of Research and Development. "That is the promise we make to our warfighters."



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    Tuesday, August 6, 2013

    Pregnancy Hormone for Traumatic Brain Injury

    http://www.wftv.com/news/news/health-med-fit-science/pregnancy-hormone-traumatic-brain-injury/nY6ww/

    Pregnancy Hormone for Traumatic Brain Injury

     
    DURHAM, N.C. —
    It can happen in an instant and change lives forever. Close to two million people are affected by traumatic brain injury every year. Worldwide, it’s a major cause of death and disability. Now, researchers are hoping something that our body produces naturally can help bring the first ever TBI treatment to those who need it.
    “As I was driving, I blacked out behind the wheel and the car went into the back of a parked 18 wheeler,” Lester Talley told Ivanhoe.
    Health issues lead to Lester Talley’s near fatal accident. The husband and father of two suffered a serious traumatic brain injury.
    “My brain had started swelling,” Lester said.
    “There really is no definitive therapy for the treatment of acute brain injury,” Daniel Laskowitz, MD, MHS, Professor Medicine (Neurology), Neurobiology, & Anesthesiology, and Director, Neurovascular Laboratories at Duke University Medical Center, told Ivanhoe.
    Lester’s wife Ashley feared the worst.
    “Seemed like my world was coming to an end,” Ashley told Ivanhoe.
    While in a coma, Lester was enrolled in a phase three trial called SyNAPSe. The study is testing if progesterone could help treat TBI.  It’s a natural hormone produced in men and women, that’s most often associated with pregnancy.
    “There is good evidence that it reduces inflammation,” Dr. Daniel Laskowitz said.
    The hormone has to be given within eight hours of an injury. It’s infused into the brain for five days straight.
    “Also, their ultimate endpoint is how they are doing at six months,” Dr. Daniel Laskowitz explained.
    Research shows the drug can rebuild the blood-brain barrier, decrease brain swelling, and cell death.
    The trial is blinded so Lester doesn’t know if he got the drug or a placebo, but in six months he’s come a long way.  He still has trouble with the left side of body and a few memory issues.
    “He remembered the most important thing, that I’m his wife.  That’s what I wanted him to remember,” Ashley said.
    More than 150 sites in 21 countries are taking part in the SyNAPSe trial. The goal is to enroll more than 1,100 TBI patients. A 2012 review of the first 200 study participants found there were no safety concerns associated with the treatment.

    http://www.wftv.com/news/news/health-med-fit-science/pregnancy-hormone-traumatic-brain-injury/nY6ww/

    Wednesday, July 31, 2013

    Traumatic Brain Injury - Dipnarine Maharaj M.D.


    Traumatic Brain Injury - Dipnarine Maharaj M.D.

    Today, we understand a great deal more about the healthy brain and its response to trauma, although science still has much to learn about how to reverse damage resulting from head injuries.

    TBI costs the country more than $56 billion a year, and more than 5 million Americans alive today have had a TBI resulting in a permanent need for help in performing daily activities. Survivors of TBI are often left with significant cognitive, behavioral, and communicative disabilities, and some patients develop long-term medical complications, such as epilepsy.

    Our work with TBI patients is some of the most important that we do.  Our brave men and women in the military deserve the very best.

    Other statistics dramatically tell the story of head injury in the United States. Each year:

    • approximately 1.4 million people experience a TBI,
    • approximately 50,000 people die from head injury,
    • approximately 1 million head-injured people are treated in hospital emergency rooms, and
    • approximately 230,000 people are hospitalized for TBI and survive.